Liver Transplant Rejection – What Should You Know?

Liver Transplant Rejection – What Should You Know?


By Rajiv Lochan, Liver Transplant Surgery

Liver Transplant Surgery is a procedure in which a whole liver or part of the liver is transplanted to a patient whose liver is damaged.

However, when a new liver is transplanted, the body immunity system considers it a threat and body try to reject the new organ. But, doctors administer certain drugs and medication which help the body accept new organ. With the advance in medical science, liver transplantation rejection rate has reduced and there have been cases where transplantations have successfully taken place.

However, in some cases, the body rejects the transplantation that may leads to organ failure.

Let us first understand what Liver Transplantation Rejection is:

What is Liver Transplant Rejection?

Liver Transplant Rejection is a simple reaction of the body to reject the new organ. When a patient is transplanted with a new organ like the liver or other, the immune system notices change in the body and tries to attack it with antibodies. This reaction of the body causes trouble for the new organ to perform and which results into rejection. The only trick doctors use here is medicate the patient in such a way that the immune system does not detect the new organ as a foreign object and let the body adapt it.

What are the signs of Liver Transplant Rejection?

Most of the symptoms of rejection are common and differ from person to person. They are general and require an eye to observe and report them to doctors. The most common symptoms of Liver Transplant Rejection are:

  1. High fever, more than 100 degrees Fahrenheit
  2. The color of the urine changes to a darker shade
  3. Fatigue
  4. Yellowing of body like in Jaundice
  5. Itching
  6. Swelling in abdomen
  7. Swelling and tenderness
  8. Headache

The symptoms of Liver Transplant Rejection are general and are not identified smoothly. Although, consult a doctor or transplant team if any of the above signs persist with the patient.

Treatment of Liver Transplant Rejection:

When liver rejection is suspected in the patient, the first thing is to take a biopsy test of the tissue of the transplanted liver. This is done only with a needle induction into the patient at the bed. Biopsy results indicate the type of treatment that will be adopted by the doctors. In general, doctors look for the presence of immune cells in the tissues.

The treatment of the rejection is generally very simple and straightforward. The first line of procedure is to adopt the use Immunosuppressive medication. Whereby, the patient is given an appropriate dosage of immunosuppressive medicines, and a routine is developed so that further liver rejection is prevented.


Liver Transplant Rejection occurs in most of the cases (20-50%) in the first year of the surgery and during the very high-risk period of 4-6 weeks of operation. Usage of immunosuppressants is an effective way to prevent rejection in the liver. However, a dismissal in the liver transplant does not affect much of the overall surgical organ. It is always advisable to consult the doctor as soon as the patient experiences any of the above symptoms. Following post instruction and eating healthy food will lower the chances of Liver Transplant Rejection.